BDBM50118028 3-Isopropyl-1-methanesulfonyl-4-(2-pyrrolidin-1-ylmethyl-oxazole-4-carbonyl)-hexahydro-pyrrolo[3,2-b]pyrrol-2-one; hydrochloride::CHEMBL542949
SMILES CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)c2coc(CN3CCCC3)n2)N(C1=O)S(C)(=O)=O
InChI Key InChIKey=MEDXAFZZWXHGBT-HYVNUMGLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50118028
Affinity DataKi: 0.160nM Kon: 4.90M-1s-1 Koff: 3.05E+4s-1Assay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of neutrophil elastase in human whole blood using MeO-Succ-Ala-Ala-Pro-Val-pNA as substrate after 30 mins by colorimetric analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
Affinity DataKoff: 3.05E+4s-1pH: 7.4Assay Description:Dissociation rate constant at pH 7.4 against ElastaseMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:The compound was evaluated for its inhibitory activity against dog neutrophil elastase using whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:The compound was evaluated for its inhibitory activity against human neutrophil elastase (HNE) using whole blood assayMore data for this Ligand-Target Pair